Bruker Avance III Biospec 94/20

General Description

System Name: Avance III BioSpec 94/20

Manufacturer: Bruker Inc. Esslingen

Type: Pre-clinical High field Magnetic Resonance Imaging (MRI) System

Instrument Operational Details

• Field Strength: 9.4T
• Bore Size: 20cm
• Gradient system: High-performance gradient systems (Standard 670mT/m, 1200mT/m wit insert)
• RF Signal Chain: Wide Band Transmitter, capable of multi-nuclear imaging; 4 RF receiver channels, with parallel imaging capabilities
• RF coils multiple volume coils, surface coils and phased array coils, cryocoil
• Control Software: Bruker Paravision V 5.2 (at installation date)
• Auxiliary Systems: Dedicated animal monitoring and gating systems, Anaesthesia support systems, Focused Ultrasound for BBB opening
• Imaging Objects and Size: Laboratory rodents (Mice, Rats), Ex-vivo Organs fixed and unfixed), Proton containing Materials
• Imaging Objects Size: Between 2g and 450g with max diameter of 70mm
• Typical System Resolution: Anatomical 50um in-plane, 75um isotropic, functional and special techniques 100-200um in plane
• General capabilities: High resolution, High contrast soft tissue in-vivo and ex-vivo imaging in structural, functional, and molecular imaging applications. Capability of repeated measurements for longitudinal studies.
• Primary application domains: Neuroscience, oncology, cardiovascular research, pharmacology, and biomarker development

Supported Modality Techniques

• Structural Anatomical Imaging, MRI microscopy (T1, T2, T2* contrast), Ultrashort and Zero Echotime Imaging (UTE, ZTE), Structural Tagging
• Diffusion-weighted imaging (DWI) including diffusion tensor imaging (DTI), NODDI etc.
• Neuro-functional MRI (fMRI), Resting State fMRI, Event related fMRI
• Relaxation Quantification (T1, T2, T2* Realxometry)
• Susceptibility weighted Imaging and Quantitative Susceptipility mapping (SWI, QSM)
• Quantification of Vascular and Flow Parameters:
• Blood Flow, Blood Volume and Perfusion Imaging
• Contrast agent based: Dynamic Susceptibilty Contrast (T2* DSC) Imaging, Dynamic Contrast Enhanced (T1 DCE) Imaging
• Non-contrast: Pulsed and Continuous Arterial Spin Labelling, (PASL, CASL)
• Vessel Imaging: Phase Contrast Angiography (PCA), Time of Flight (TOF) Angiography
• Magnetization Transfer: Chemical Exchange Transfer Imaging (CEST), Magnetic Transfer Ratio Imaging (MTR)
• Metabolite detection: Magnetic Resonance Spectroscopy (MRS).

• Pre-clinical High field Magnetic Resonance Imaging (MRI) System