Description
General Description
System Name: Momentum Magnetic Particle Imaging
Manufacturer: Magnetic Insight Inc.
Type: Pre-clinical Magnetic Particle Imaging (MPI) System
Operational Details
- Signal Source: Injectable Tracers, Superparamagnetic Nanoparticles, mostly Iron Oxide (SPIONs)
- Typical System Sensitivity: Fe detection and location in Nanogram range
- Typical System Resolution: Approximately 1 mm – depending on tracer quality
- Instrument operational details:
- Imaging Principle: Gantry based Field Free Line (FFL) Scanner, using x-space reconstruction to obtain 3D tomographic volumes and/or 2D projections
- Bore Size: 40mm
- Excitation Field (Drive Field): - 45kHz Oscillating magnetic field, 0-26mT variable amplitude
- 1 or 2 channel operation modes for non-isotropic and isotropic imaging
- Gradient Strength: Variable 2- 6.1 T/m depending on resolution and sensitivity requirements
- Field of View: Up to 12 × 6 × 6 cm (application dependent)
- Control Software: Momentum MPI Acquisition and Reconstruction Software
- Auxiliary Systems: Relaxometry module, animal handling system, physiological monitoring, CT co-registration compatibility
- Imaging Objects: Murine Laboratory models, excised tissues containing SPION tracers and novel magnetic tracers and other magnetic materials
- Imaging Object Size: max diameter 35mm,instrument is a dedicated mouse scanner
- General capabilities: Quantitative, background-free molecular imaging of iron oxide nanoparticle tracers with high sensitivity and absolute tracer quantification suitable for longitudinal studies
- Primary application domains: Cell tracking, cancer imaging, vascular imaging, inflammation, immunology, regenerative medicine, drug delivery, nanoparticle development and characterization
Supported Modality Techniques
- 2D projection imaging in arbitrary directions
- 3D tomographic MPI
- Tracer quantification and concentration mapping, tracer biodistribution studies
- Cell tracking: In-vivo detection of Fe incubated cells
- Molecular Imaging: Detection of targeted magnetic particles
- Vascular and Perfusion imaging
- Nanoparticle Bulk Relaxometry: Neel and Brown Relaxation Characterization, Tracer sensitivity and resolution studies
- Dynamic MPI and Multi-timepoint longitudinal imaging: Tracer retainment studies, Tracer circulation studies
Instrument Type(s)
- Pre-clinical Magnetic Particle Imaging (MPI) System